Janine S. Ladislaw, Ph.D.

Associate, Registered Patent Attorney - Boston

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Dr. Janine Ladislaw prepares and prosecutes patent applications, develops strategy for patent prosecution, performs patentability and freedom-to-operate analyses, and provides clients with due diligence assessments of patent portfolios in connection with technology transactions and acquisitions. She has obtained numerous domestic and foreign patents for emerging companies, public corporations, universities, and independent research institutions in a wide range of technical areas, including the fields of polymer chemistry, materials science, pharmaceuticals, small molecule drug discovery, synthetic methods, clean technology, biochemistry, and laboratory equipment and devices. Janine has been the lead chemist on the patent portfolio relating to a small molecule kinase inhibitor that is FDA-approved for the treatment of various leukemias and lymphomas; the drug has a projected net revenue of over $2.4 billion for 2017.

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Education:

  • Boston College Law School, J.D.
  • University of Pennsylvania, Ph.D. in Organic and Polymer Chemistry
  • College of William and Mary, B.S. in Chemistry, cum laude

Representative Experience

Representative list of patents obtained and patent applications drafted

Applied Polymeric Materials

  • Three-dimensional photoresists via functionalization of polymer thin films fabricated by iCVD (US9163307)
  • Universal solution for growing thin films of electrically conductive nanostructures (US9017773)
  • Nanostructured physically-associating hydrogels for injectable, responsive, and tough biomaterials (US8916683)
  • Hard, impermeable, flexible and conformal organic coatings (US8552131)
  • Methods for producing multiple distinct transistors from a single semiconductor (US7993959)
  • Embolization using degradable crosslinked hydrogels (US7838699)
  • Porous catalytic matrices for elimination of toxicants found in tobacco combustion products (US2014/0311507)
  • Antifouling and chlorine-resistant ultrathin coatings on reverse osmosis membranes (US2014/0299538)
  • Chromatography membranes stable under caustic conditions (US2014/0273158)
  • Porous polymeric particles and methods of making and using them (US2014/0251927)
  • Superhydrophobic and oleophobic functional coatings comprised of grafted crystalline polymers comprising perfluoroalkyl moieties (US2013/0280485)
  • Selenophene-based low band gap active layers by chemical vapor deposition (US2013/0089659)

Systems and Formulations for Delivery of Pharmaceuticals

  • Drugs and gene carrier particles that rapidly move through mucous barriers (US8957034)
  • Controlled release pharmaceutical delivery device and process for preparation thereof (US7906143)
  • Conjugates comprising a biodegradable polymer and uses therefor (US7785618)
  • Lipid-containing compositions and methods for treating cancer (WO2014/110555)

Alternative Fuels

  • Glycerol containing fuel mixture for direct injection engines (US8679202)
  • Gene knockout mesophilic and thermophilic organisms, and methods of use thereof, such as for the production of ethanol (US8435770)
  • Microorganisms engineered to use unconventional sources of nitrogen (WO2014/107660)

Drugs and Biologics

  • Compounds and methods for treating mammalian gastrointestinal microbial infections (US8969342)
  • Tricyclic proteasome activity enhancing compounds (US8933087)
  • Aminooxazole inhibitors of cyclin dependent kinases(US8551992)
  • Histone deacetylase inhibitors and methods of use thereof (US8222451)
  • CD4-mimetic inhibitors of HIV-1 entry and methods of use thereof (US2014/0350113)
  • Combination therapies for enhancing protein degradation (US2014/0275169)
  • Small molecule inhibitors of ebola and lassa fever viruses and methods of use (US2013/0231332)
  • Biotin complexes for treatment and diagnosis of Alzheimer’s disease (WO2014/036427)

Imaging Tracers, Probes and Diagnostic Methods

  • Catalytic radiofluorination (US8900550)
  • High-throughput methods for determining pharmacological levels of plasma D-serine (US8778688)
  • Compounds and compositions for the detection and treatment of Alzheimer's disease and related disorders (US8450466)
  • Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process (US8114379)

Representative intellectual property-related diligence and opinion engagements, litigation cases, appeals, and post-grant proceedings

  • Provided a patent invalidity opinion relating to the purification of enantiomerically pure intermediates in pharmaceutical manufacturing
  • Helped investors in life science companies evaluate the patent portfolios and FDA exclusivities that protect the value of their investments
  • Appealed to the USPTO Patent Trial and Appeal Board (PTAB) a rejection of claims to a nasal spray formulation of a corticosteroid for treatment of allergic rhinitis
  • Served as technical lead in a series of Hatch-Waxman patent infringement actions, defending a patent portfolio covering a drug used for treating end-stage renal disease against ANDA filers’ invalidity and non-infringement contentions
  • Assisted European counsel on behalf of patent owners in opposition proceedings before the European Patent Office (EPO)
  • Advised Japanese counsel on behalf of patent owner in an invalidation trial before the Japanese Patent Office (JPO)

Professional Experience

  • Teaching Fellow, Organic Chemistry I and Experimental Organic Chemistry Laboratory, Department of Chemistry, University of Pennsylvania
  • Lligadas, G.; Ladislaw, J. S.; Guliashvili, T.; Percec, V. Functionally Terminated Poly(methyl acrylate) by SET-LRP Initiated with CHBr3 and CHI3. J. Polym. Sci. Part A: Polym. Chem. 2008, 46, 278-288
  • Percec, V.; Guliashvili, T.; Ladislaw, J. S.; Wistrand, A.; Stjerndahl, A.; Sienkowska, M. J.; Monteiro, M. J.; Sahoo, S. Ultrafast Synthesis of Ultrahigh Molar Mass Polymers by Metal-Catalyzed Living Radical Polymerization of Acrylates, Methacrylates, and Vinyl Chloride Mediated by SET at 25 oC. J. Am. Chem. Soc. 2006, 128, 14156-14165 [Highlighted in Chemical and Engineering News, October 30, 2006, 84(44), 40-41]
  • Mamdouh, W.; Uji-i, H.; Ladislaw, J. S.; Dulcey, A. E.; Percec, V.; De Schryver, F. C.; De Feyter, S. Solvent Controlled Self-Assembly at the Liquid/Solid Interface Revealed by STM. J. Am. Chem. Soc. 2006, 128(1), 317-325
  • Percec, V.; Dulcey, A. E.; Peterca, M.; Ilies, M.; Ladislaw, J.; Rosen, B. M.; Edlund, U.; Heiney, P. A. The Internal Structure of Helical Pores Self-Assembled from Dendritic Dipeptides is Stereochemically Programmed and Allosterically Regulated. Angew. Chem., Int. Ed. 2005, 44, 6516-6521
  • Delozier, D. M.; Orwoll, R. A.; Cahoon, J. F.; Ladislaw, J. S.; Smith, J. G.; Connell, J. W. Polyimide nanocomposites prepared with a novel aromatic surfactant. High Performance Polymers 2003, 15(3), 329-346
  • Delozier, D. M.; Orwoll, R. A.; Cahoon, J. F.; Ladislaw, J. S.; Smith, J. G.; Connell, J. W. Polyimide nanocomposites prepared from high-temperature, reduced charge organo-clays. Polymer 2003, 44(8), 2231-2241

Honors

  • American Chemical Society Women Chemists Committee Travel Award sponsored by Eli Lilly and Company

Involvement

  • Boston Bar Association (BBA), Co-Chair of the Life Sciences Committee, Intellectual Property Section (2016-present)
  • American Chemical Society (ACS), Member
  • American Intellectual Property Law Association (AIPLA), Member
  • Association of University Technology Managers (AUTM), Member
  • Boston Patent Law Association (BPLA), Member
  • Boston Intellectual Property American Inn of Court, Member
  • Women's Bar Association (WBA) of Massachusetts, Member
  • Intellectual Property and Technology Forum, Boston College Law School, Article Reviewer (2010-2012)
  • Consumer Genetics Conference, Boston, MA, Volunteer (2009-2010)
  • “How to Create Value from Inventions,” Harvard Business School New Venture Competition Legal Series; presenter (February 2018) 
  • "Top IP Cases in 2017 In-House Counsel Need to Know," Foley Hoag seminar and webinar; presenter (December 2017)
  • “Beyond the Bench: Careers in Intellectual Property,” 254th American Chemical Society National Meeting & Exposition, Chemistry and the Law Division, Washington, DC; panelist (August 2017)
  • Harvard Medical School, Department of Biological Chemistry and Molecular Pharmacology Career Panel 2015, Boston, MA; presenter (September 2015)
  • "Corporate and Patent Law Basics for Academic Researchers," F.M. Kirby Neurobiology Center Seminar Series, Children's Hospital Boston and Harvard Medical School, Boston, MA; presenter (June 2012)
  • South Jersey 4-H Teen Conference, Exploring Science, Engineering, and Technology; presenter (March 2009)
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Bar Admissions

  • Massachusetts

Court Admissions

  • U.S. Patent & Trademark Office (Agency)