Thi K. Dio, Ph.D.

Partner, Registered Patent Attorney - Boston

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Contact Information


  • Suffolk University Law School, J.D.
  • Cornell University, Ph.D. in Biochemistry, Molecular and Cell Biology; minor in Biophysics
  • Cornell University, B.A. in Chemistry and Biological Sciences



Representative Experience

  • Represented numerous technology clients to successfully obtain domestic and international patent protection for hundreds of inventions in varied technologies.
  • Performed portfolio analysis, freedom-to-operate, and due diligence for biopharmaceutical companies in various high-value commercial transactions and global strategic collaboration agreements.
  • Conducted defensive review and invalidity analysis of patents licensed by a multinational biotechnology company as part of licensing negotiations.
  • Prosecuted patent estate for global manufacturer of rapid point-of-care diagnostic tests in successful merger with large health care company.
  • Performed freedom-to-operate review for life sciences company having best-in-class quality control tools for next generation sequencing clinical laboratories and in vitro diagnostic assay development.
  • Established and developed patent portfolio for biotechnology company specializing in immunoassay and molecular probe kits and instruments for the diagnosis of infectious diseases resulting in successful acquisition to competitor global, high-growth diagnostics company.
  • Prepared non-infringement and invalidity analyses for biotechnology companies against asserted patents.
  • Provided litigation counsel against accusations of infringement in various technological fields.

Professional Experience

  • Teaching Fellow, Cornell University Molecular Biology & Genetics Department
  • Graduate course in Protein Structure, Dynamics, and Function
  • Undergraduate Laboratory in Biochemistry and Molecular Biology
  • Researched patent data for article entitled “New England’s top life sciences patent holders,” MASS HIGH TECH (MHT) THE JOURNAL OF NEW ENGLAND TECHNOLOGY, March 30, 2011 
  • Researched patent data for article entitled “Top 30 New England Patent Holders,” MASS HIGH TECH (MHT) THE JOURNAL OF NEW ENGLAND TECHNOLOGY, January 19, 2011 
  • Researched patent data for article entitled “Life Sciences Patent Holders,” MASS HIGH TECH (MHT) THE JOURNAL OF NEW ENGLAND TECHNOLOGY, March 31, 2010 
  • Co-Author, Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010 
  • Researched patent data for article entitled “Patents become more granular at tech companies,” MASS HIGH TECH (MHT) THE JOURNAL OF NEW ENGLAND TECHNOLOGY, October 7, 2009 
  • Co-Author, Two isoforms of tissue transglutaminase mediate opposing cellular fates, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES USA, 2006  
  • Co-Author, The Cool-1/beta Pix protein serves as an essential regulatory node for EGF receptor- and Src-mediated cell growth, NATURE CELL BIOLOGY, 2006 
  • Co-Author, Structural basis of m7GpppG binding to the nuclear cap-binding complex, NATURE STRUCTURAL BIOLOGY, 2002 
  • Co-Author, Inhibition of sequence-specific proteolysis using compounds that target the substrate rather than the enzyme, CHEMISTRY AND BIOLOGY, 2001


  • Ruth L. Kirschstein National Research Service Award (NRSA) Dana Farber Cancer Institute Research Training Fellowship, National Institutes of Health
  • Cellular and Molecular Biology Senior Training Grant Award
  • Graduate Assistance in Areas of National Need (GAANN) Teaching and Research Fellowship, Department of Education
  • President’s Council of Cornell Women Tradition Fellow


  • Boston Patent Law Association, Biotechnology Committee (Co-chair)
  • Boston Bar Association
  • State Bar of Texas, Intellectual Property Law Section Computer Law Section
  • Dallas Bar Association, Intellectual Property Law Section 
  • American Chemical Society (ACS) 
  • American Association for the Advancement of Sciences (AAAS)
  • Assisted in drafting "2009 Federal Circuit and Legislative Update for Patents," 27th Annual National CLE Conference, Vail, Colorado, January 2010
  • Assisted in drafting presentation entitled "Overview of the Requirements for Patentability," AIPLA Boot Camp: 2008 Practical Patent Prosecution Training for New Lawyers, Alexandria, VA (August 2009 and August 2008)
  • A Cdc42/Rac1-mTOR signaling pathway targets Ran and the importins to regulate the nuclear cap-binding complex (CBC), duVigneaud Symposium, New York, NY, 2006
  • Role of the Ran GTPase in Heregulin-Initiated Signals to the Cap-Binding Complex, FASEB Conference, Snowmass, CO, 2004
  • Epitope-Binding Peptides and Peptidomimetic Compounds: Towards Low Molecular Weight Monoclonal Antibody Equivalents, Cambridge Healthtech Institute, Baltimore, MD, 2000
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Bar Admissions

  • Massachusetts
  • Texas

Court Admissions

  • U.S. Patent & Trademark Office (Agency)